Advances in spectroscopy for lasers and sensing by Baldassare Di Bartolo; Ottavio Forte; International School

By Baldassare Di Bartolo; Ottavio Forte; International School of Atomic and Molecular Spectroscopy.; North Atlantic Treaty Organization

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P Laine, D. R Lim, H. A Haus, and L. C Kimerling, and S. T. 25 73(2000). 19. L. Tong, J. Lou, R. R. Gattass, S. He, X. Chen, L. Liu, and E. 5, 259262(2005). 20. F. Mikes, Y. Yang, I. Teraoka, T. Ishigure, Y. Koike, and Y. Okamoto,”Synthesis and Characterization of an Amorphous Perfluropolymer: Poly(perfluoro-2methylene-4-methyl-1,3-dioxolane”, Macromolecules 38, 4237-4245(2005). 21. O. Gaathon, W. Jeck, I. Teraoka, and S. Arnold (in progress). it, Abstract The first laser has been invented in 1960, and since then the laser field exploded almost exponentially, covering a spectral range from less than 1 Å to more than 1 mm.

S. C. Ching, P. T. Leung, and K. Young, “Optical processes in microcavities-the role of quasinormal modes,” in Optical process in microcavity, R. K. Chang, and A. J. Campillo, eds. (World Scientific, Singapore, 1996), pp. 1-76. 10. M. Noto, F. Vollmer, D. Keng, I. Teraoka, and S. Arnold, “Nanolayer Characterization through Wavelength Multiplexing a Microsphere Resonator”, Opt. Lett. 30, 510-512(2005). 11. J. P Laine, B. E. Little, and H. A. Haus, “Etch-eroded fiber coupler for whisperinggallery-mode excitation in high-Q silica microspheres,” IEEE Photon.

This compound reacts with the silanol groups on the silica surface and at biological pH leaves an exposed NH3+ rug. This is ideal for a protein that acquires a negative charge at this pH; the charge attraction holds the protein in place. Many protein acquire a net negative charge. So the attachment to the surface is not specific. To make the attachment specific requires the lock to key relationship that we spoke about earlier. A graphic example can be illustrated in the case of BSA. By chemically attaching biotin (vitamin H) to BSA we generate a modified protein with one major suitor.

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